promethazine suppository stability at room temperature
Promethazine HCl 50mg. Unable to load your collection due to an error, Unable to load your delegates due to an error. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. Vaginal Suppositories Allow suppository to reach room temperature just prior to administration. tell your doctor if you have or have ever had an enlarged prostate (a male reproductive gland); glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); seizures; ulcers; blockage in the passage between the stomach and intestine; blockage in the bladder; asthma or other lung disease; sleep apnea; cancer;any condition that affects the production of blood cells in your bone marrow; or heart or liver disease. Promethazine HCl Suppositories are useful for: Perennial and seasonal allergic rhinitis. 2 years and older: Treatment: Oral or Rectal: 1.1 mg/kg orally or rectally every 4 to 6 hours as needed. Allergic conjunctivitis due to inhalant allergens and foods. Would you like email updates of new search results? Bookshelf 20 N ), More about getting RSS News & Updates from DailyMed, 12 in 1 BOX; Type 0: Not a Combination Product, 1000 in 1 BOX; Type 0: Not a Combination Product, Cosette Pharmaceuticals NC Laboratories, LLC, analysis(0713-0526, 0713-0536) , label(0713-0526, 0713-0536) , manufacture(0713-0526, 0713-0536) , pack(0713-0526, 0713-0536), 6 If you take this medicine (promethazine suppositories) on a regular basis, take a missed dose as soon as you think about it. In case of overdose, call the poison control helpline at 1-800-222-1222. When given concomitantly with Promethazine HCl Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. WARNINGS Use in Pediatric Patients). Dosage must be individualized. Parenteral: 25 mg IM or IV once, and may be repeated within 2 hours if necessary Promethazine HCl Suppositories, USP are useful for: Webafter 24 hours of storage at room- temperature, when stored in a cool place (815 C), and when stored at room-temperature (1530 C). Check with your pharmacist. Keep all drugs out of the reach of children and pets. any drug without checking with your doctor. R)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Follow all instructions closely. tell your doctor and pharmacist if you are allergic to promethazine, other phenothiazines (certain medications used to treat mental illness, nausea, vomiting, severe hiccups, and other conditions) or any other medications. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or, Promethazine HCl Rectal Suppositories are contraindicated for children under 2 years of age (, All Drug Promethazine HCl Suppositories, USP are for rectal administration only. Some drugs may have another patient information leaflet. Vials stored at room temperature should not be returned to the refrigerator. Stavchansky S, Wallace JE, Geary R, Hecht G, Robb CA, Wu P. J Pharm Sci. Administration of 12.5 to 25 mg promethazine HCl by rectal suppository at bedtime will provide sedation in children. WARNINGSRespiratory Depression). Rectally administered indomethacin should be used with caution in patients with hemorrhoids, anal, or rectal inflammation. Avoid sun, sunlamps, and tanning beds. Applies to the following strengths: 12.5 mg; 25 mg; 25 mg/mL; 50 mg; 25 mg/5 mL; 50 mg/mL; 6.25 mg/5 mL; 25 mg/25 mL-NaCl 0.9%. and transmitted securely. 25 mg, white, bullet-shaped suppository wrapped in silver foil. Control) Pramlintide injection (Symlin) Promethazine suppositories (Promethegan) Proparacaine ophthalmic. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Promethazine HCl Suppositories (Promethazine Hydrochloride Suppositories) may treat, side effects, dosage, drug interactions, warnings, patient 2013 Mar;75(2):143-8. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). You may get sunburned more easily. The syrup version of promethazine should be in a light-protected bottle with the lid tightly closed at all times. PROMETHAZINE HCL SUPPOSITORIES ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE (see WARNINGS-Black Box Warning and Use in Pediatric Patients). Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in children who are 2 years of age older and 1 inch (2.5 centimeters) in adults. Acidosis and electrolyte losses should be corrected. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Talk to your doctor about the risks of giving promethazine to your child. Take promethazine exactly as directed. Avoid prolonged exposure to the sun. When promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. Bookshelf Before Extrapyramidal reactions may be treated with anticholinergic antiparkinsonian agents, diphenhydramine, or barbiturates. WebThe NDC Packaged Code 0713-0526-12 is assigned to a package of 12 suppository in 1 box of Promethegan, a human prescription drug labeled by Cosette Pharmaceuticals, Inc.. WebPromethazine HCl Suppositories are for rectal administration only. (current), promethazine HCl 12.5 MG Rectal Suppository, promethazine hydrochloride 12.5 MG Rectal Suppository, promethazine hydrochloride 12.5 MG Rectal Suppository [Promethegan], promethazine HCl 25 MG Rectal Suppository, promethazine hydrochloride 25 MG Rectal Suppository, promethazine hydrochloride 25 MG Rectal Suppository [Promethegan]. Take the missed dose as soon as you remember it. Allergic conjunctivitis due to inhalant allergens and foods. Preoperative, postoperative, or obstetric sedation, Relief of apprehension and production of light sleep from which the patient can be easily aroused. WARNINGSCNS Depression and Files, Presentations Dosage must be individualized. Minor transfusion and/or amelioration of allergic reactions may be controlled with 12.5 mg doses. Be ready to tell or show what was Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. Many times this medicine (promethazine suppositories) is taken on an as needed basis. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication. Remove the wrapper. taken, how much, and when it happened. Promethazine is an H pharmacist if you have questions about the best way to throw out drugs. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. WebTo insert a promethazine suppository, follow these steps: If the suppository feels soft, hold it under cold, running water for 1 minute. & Articles, All Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Available for Android and iOS devices. Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. This method is capable of distinguishing Unauthorized use of these marks is strictly prohibited. All Rights Reserved. It is soluble in water and freely soluble in alcohol. The product's dosage form is suppository and is administered via rectal form. You will need to talk about the benefits and risks hUV?Rr$F/~H>d'K[U[\6 n=>r,+wk2rP#hqB8&\,d `S6XGfRFLm1b%Ux/w4 *uU=pk6M;]-I%d.@TdzJ]C//RbU=8q]W0,75ni. Promethazine HCl Suppositories may lower seizure threshold. Citations, PRECAUTIONS- Information for Patients and Drug Interactions, Carcinogenesis, Mutagenesis, Impairment of Fertility, Report Adverse For all patients taking this medicine (promethazine suppositories): This is not a list of all drugs or health problems that interact with this medicine (promethazine suppositories). Also tell the child's doctor if the child has not been drinking normally, has had excessive vomiting or diarrhea, or appears dehydrated. Perennial and seasonal allergic rhinitis. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment Allergic conjunctivitis due to inhalant allergens and foods. http://goo.gl/c4Rm4p WARNING: PROMETHAZINE HCL SUPPOSITORIES SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. Active and prophylactic treatment of motion sickness. Clipboard, Search History, and several other advanced features are temporarily unavailable. Once treatment begins, the dose should be reduced to the smallest effective amount needed to control symptoms. 30 days. 2 0 obj POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HCL SUPPOSITORIES IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. This drug should be administered at a rate no greater than 25 mg/min. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or PRECAUTIONS- Information for Patients and Drug Interactions). Take promethazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Promethazine suppositories are for rectal use only. Do not try to swallow the suppositories or insert in any other part of your body. Protect the medication from light. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. If you experience any of the following symptoms, call your doctor immediately: If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( The release of indomethacin from fatty-base suppositories, which had been stored at a low (4 degrees C) and a high (25-30 degrees C) temperature for about one month, was examined in vitro and in vivo. Low white blood cell counts have happened with this medicine (promethazine suppositories). Promethazine is also used to prevent and control nausea and vomiting that may occur after surgery, and with other medications to help relieve pain after surgery. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Nonteratogenic Effects.). breathing. Off-label information indicates unopened bottle stable when maintained at continuous room Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Where do I get this medication? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Promethazine can cause side effects. Paradoxical Reactions <> Promethazine HCl 25mg. Copy the URL below and paste it into your RSS Reader application. Files, All Mapping 4 0 obj Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use. The effect on later growth and development of the newborn is unknown. If your child is throwing up for an unknown reason. RxNorm, 1 0 obj Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Ask your doctor or pharmacist if you do not know if a medication you are allergic to is a phenothiazine. government site. Stability at Room Temperature** FOR SPECIFIC INFORMATION, CONTACT MANUFACTURER. In the event that vasopressors are considered for the management of severe hypotension that does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered. Refrigerator settings should be mid-range at +5C (41F) to allow the highest Promethazine HCl is a racemic compound; the empirical formula is C WebStore the tablets and syrup at room temperature. Rectal suppositories Never take suppositories by mouth. ask your doctor about the safe use of alcohol while you are taking this medication. Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene. Box of 12 NDC 0713-0526-12 It may be given to you for other reasons. Do not handle too much. Updated This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Antiemetic therapy in postoperative patients. Box of 1000 NDC 0713-0536-10 Glucose Tolerance Test When promethazine is used to treat motion sickness, it is taken 30 to 60 minutes before travel and again after 8 to 12 hours if needed. The information is not a substitute for medical care. Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. PMC 65 years and older: Elderly patients should be given lower initial doses and should be closely monitored for adverse events. Only in cases of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. You must check Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. IV: Treatment should be injected into a large vein, avoiding sites in the hand/wrist if possible. Promethazine HCl Suppositories may lower seizure threshold. Call your doctor right away if you have slow, shallow, or trouble An official website of the United States government.
Resident Owned Mobile Home Parks In Collier County Florida,
Articles P